HUSH complex binds LINE1 (L1) RNA

Stable Identifier
R-HSA-9843990
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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HUSH complex binds LINE1 (L1) RNA
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Both Periphilin (PPHLN1) (Castello et al. 2012, Seczynska et al. 2022) and TASOR (Queiroz et al. 2019, Douse et al. 2020) of the HUSH complex bind RNA. The HUSH complex binds transcripts from active LINE1 retroelements prior to transcriptional repression of those elements (Seczynska et al. 2022). Increased binding of the HUSH complex to LINE1 retroelements is observed upon transcription through the LINE1 retroelement (Liu et al. 2018). The C-terminal region of PPHLN1 binds TASOR and the N-terminal region self-aggregates and probably binds RNA (Prigozhin et al. 2020).
Literature References
PubMed ID Title Journal Year
30607034 Comprehensive identification of RNA-protein interactions in any organism using orthogonal organic phase separation (OOPS)

Queiroz, RML, Smith, T, Villanueva, E, Marti-Solano, M, Monti, M, Pizzinga, M, Mirea, DM, Ramakrishna, M, Harvey, RF, Dezi, V, Thomas, GH, Willis, AE, Lilley, KS

Nat Biotechnol 2019
22658674 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

Castello, A, Fischer, B, Eichelbaum, K, Horos, R, Beckmann, BM, Strein, C, Davey, NE, Humphreys, DT, Preiss, T, Steinmetz, LM, Krijgsveld, J, Hentze, MW

Cell 2012
33009411 TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

Douse, CH, Tchasovnikarova, IA, Timms, RT, Protasio, AV, Seczynska, M, Prigozhin, DM, Albecka, A, Wagstaff, J, Williamson, JC, Freund, SMV, Lehner, PJ, Modis, Y

Nat Commun 2020
34794168 Genome surveillance by HUSH-mediated silencing of intronless mobile elements

Seczynska, M, Bloor, S, Cuesta, SM, Lehner, PJ

Nature 2022
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Authored
May, B  (2023-09-11)
Reviewed
Bourc'his, D  (2024-05-14)
Fernandes, LP  (2024-05-14)
Created
May, B  (2023-09-12)
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