Reactome | CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin

CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin

Stable Identifier

R-HSA-9843978

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin

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TRIM28 (KAP1) binds the chromoshadow domain of CBX5 (HP1alpha) (Ryan et al. 1999, Ayyanathan et al. 2003, Lechner et al. 2005, Sripathy et al. 2006). One TRIM28 dimer binds one CBX5 dimer (Fonti et al. 2019). Dimerization of CBX5 increases chromatin stiffness, but CBX5 does not appear to affect transcription, local chromatin compaction, or histone methylation (Strom et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
31427381	KAP1 is an antiparallel dimer with a functional asymmetry Fonti, G, Marcaida, MJ, Bryan, LC, Träger, S, Kalantzi, AS, Helleboid, PJ, Demurtas, D, Tully, MD, Grudinin, S, Trono, D, Fierz, B, Dal Peraro, M	Life Sci Alliance	2019
15882967	The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain Lechner, MS, Schultz, DC, Negorev, D, Maul, GG, Rauscher, FJ	Biochem Biophys Res Commun	2005
12869583	Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation Ayyanathan, K, Lechner, MS, Bell, P, Maul, GG, Schultz, DC, Yamada, Y, Tanaka, K, Torigoe, K, Rauscher FJ, 3rd	Genes Dev	2003
10330177	KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing Ryan, RF, Schultz, DC, Ayyanathan, K, Singh, PB, Friedman, JR, Fredericks, WJ, Rauscher FJ, 3rd	Mol Cell Biol	1999
16954381	The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression Sripathy, SP, Stevens, J, Schultz, DC	Mol Cell Biol	2006