NuRD complex binds SUMO2-6K-TRIM28:KRAB-ZNF:retroelement

Stable Identifier
R-HSA-9842876
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NuRD complex binds SUMO2-6K-TRIM28:KRAB-ZNF:retroelement
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TRIM28 binds CHD3 (Mi-2alpha), a subunit of the NuRD repressor complex, therefore TRIM28 is inferred to associate with the NuRD complex (Ivanov et al. 2007 and inferred from bovine TRIM28 binding human CHD3). The NuRD complex contains histone deacetylases and histone deacetylase activity is required for full repression by the KRAB-ZFP:TRIM28 complex (Schultz et al. 2001).
Literature References
PubMed ID Title Journal Year
18082607 PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing

Yap, KL, Negorev, DG, Ivanov, AV, Schultz, DC, Peng, H, Fredericks, WJ, Sadofsky, MJ, Psulkowski, E, Rauscher FJ, 3rd, White, DE, Yurchenko, V, Zhou, MM, Maul, GG

Mol Cell 2007
Participants
Input
Output
Participates
as an event of
Inferred From
TRIM28 (KAP1) binds CHD3 (Mi-2alpha) (Bos taurus)
Authored
May, B  (2023-08-26)
Reviewed
Bourc'his, D  (2024-05-14)
Fernandes, LP  (2024-05-14)
Created
May, B  (2023-08-29)
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