PKR binds viral dsRNA

Stable Identifier
R-HSA-9839016
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PKR binds viral dsRNA
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Viral dsRNA is the primary activator of PKR (EIF2AK2). dsRNA viruses, such as Reoviridae and Birnaviridae, have dsRNA as their genomic material. Other viruses, such as some positive-sense RNA viruses, can generate dsRNA intermediates during replication. dsRNA binds to one or both of the two double-stranded RNA-binding motifs (dsRBMs) of PKR (Meurs et al, 1990; Patel $ Sen, 1992; Patel & Sen, 1998; Zhang et al, 2001; reviewed by Bou-Nader et al, 2019). This interaction, and the following recruitment of PKR to stress granules, is facilitated by the MAVS protein (Zhang et al, 2014).
Literature References
PubMed ID Title Journal Year
11337501 Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop

Dever, TE, Tian, B, Hinnebusch, AG, Romano, PR, Mathews, MB, Zhang, F, Nagamura-Inoue, T, Ozato, K

J Biol Chem 2001
9819388 Requirement of PKR dimerization mediated by specific hydrophobic residues for its activation by double-stranded RNA and its antigrowth effects in yeast

Patel, RC, Sen, GC

Mol Cell Biol 1998
30770398 The search for a PKR code-differential regulation of protein kinase R activity by diverse RNA and protein regulators

Gordon, JM, Bou-Nader, C, Henderson, FE, Zhang, J

RNA 2019
1373135 Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase

Patel, RC, Sen, GC

J Biol Chem 1992
24659800 IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its activation

Pu, J, Li, Y, Wu, S, Xia, J, Huang, X, Zhang, P, Zhang, P, He, J, Feng, L, Xie, J

J Cell Sci 2014
1695551 Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

Hovanessian, AG, Thomas, NS, Williams, BR, Galabru, J, Meurs, E, Kerr, IM, Chong, K

Cell 1990
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MAVS [mitochondrial outer membrane] (Homo sapiens)
Disease
Name Identifier Synonyms
viral infectious disease DOID:934 Viral disease, virus infection, virus infection
Authored
Stephan, R  (2023-08-15)
Reviewed
Patel, RC  (2023-08-16)
Created
Stephan, R  (2023-06-29)
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