GRSF1 binds RNA containing quadruplex guanosine

Stable Identifier
R-HSA-9836993
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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GRSF1 binds RNA containing quadruplex guanosine
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GRSF1 contains three RNA-binding domains, which are all required for high affinity RNA binding (Sofi et al. 2018). GRSF1 binds G-quadruplex secondary structures in RNA and promotes their melting, facilitating degradation of some RNAs by the SUPV3L1:PNPT1 complex (Pietras et al. 2018). However, GRSF1 acts to stabilize other RNAs and facilitates the translation of some mRNAs (Antonicka et al. 2013), therefore the melting of quadruplex G structures appears to have pleiotropic effects. GRSF1 also participates in processing large mitochondrial precursor transcripts to produce tRNAs, rRNAs, and mRNAs (Jourdain et al. 2013).
Literature References
PubMed ID Title Journal Year
29967381 Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria

Dziembowski, A, Stepien, PP, Szczesny, RJ, Szewczyk, M, Wojcik, MA, Kulinski, TM, Borowski, LS, Cysewski, D, Pietras, Z

Nat Commun 2018
29366917 Functional characterization of naturally occurring genetic variations of the human guanine-rich RNA sequence binding factor 1 (GRSF1)

Dumoulin, B, Kühn, H, Fitzgerald, JC, Stehling, S, Ufer, C, Sofi, S, Jähn, D

Biochim Biophys Acta Gen Subj 2018
29288125 Functional characterization of isolated RNA-binding domains of the GRSF1 protein

Kühn, H, Stehling, S, Niewienda, A, Ufer, C, Janek, K, Sofi, S

Biochim Biophys Acta Gen Subj 2018
23473033 The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression

Paupe, V, Antonicka, H, Sasarman, F, Shoubridge, EA, Nishimura, T

Cell Metab 2013
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Authored
May, B  (2023-06-06)
Reviewed
Anonymous, R  (2023-08-09)
Created
May, B  (2023-06-07)
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