The RSV glycoprotein (G) is a major surface protein that plays a crucial role in viral attachment and entry into host cells. The viral G protein was found to bind to a complex formed by two Toll-like receptors (TLRs), specifically TLR2 and TLR6. TLRs are pattern recognition receptors (PRRs) that sense pathogen-associated molecular patterns (PAMPs) to trigger immune response. The interaction between hRSV G and TLR2:TLR6 is thought to activate the TLR2:TLR6 signaling cascade leading to the production of various immune mediators, including pro-inflammatory cytokines, chemokines, and type I interferons in human primary small airway epithelial cells (HSAECs) (Alshaghdali K et al. 2021). In vivo studies using knockout mice further confirm an involvement of TLR2:TLR6 in recognition of RSV (Murawski MR et al. 2009).