Reactome | p-PKR dimer phosphorylates CDK1

p-PKR dimer phosphorylates CDK1

Stable Identifier

R-HSA-9836184

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cyclin-dependent kinase 1 (CDK1, CDC2), as subunit of a complex with Cyclin B, regulates and promotes multiple transitions in the cell cycle. Protein kinase R (PKR, EIF2AK2) phosphorylates CDK1 at Y4, marking it for subsequent ubiquitination and proteosomal degradation, leading to G2/M arrest and apoptosis, in particular under genotoxic conditions in cancer therapy, and as part of the antiviral response (Dagon et al, 2001; Yoon et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
11781817	Double-stranded RNA-dependent protein kinase, PKR, down-regulates CDC2/cyclin B1 and induces apoptosis in non-transformed but not in v-mos transformed cells Dagon, Y, Dovrat, S, Vilchik, S, Hacohen, D, Shlomo, G, Sredni, B, Salzberg, S, Nir, U	Oncogene	2001
20395957	New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses Yoon, CH, Miah, MA, Kim, KP, Bae, YS	EMBO Rep	2010