VTRNA2-1 binds PKR

Stable Identifier
R-HSA-9835992
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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VTRNA2-1 binds PKR
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Several cellular RNA species act as PKR inhibitors, supporting general protein translation. For instance, VTRNA2-1 (ns886, miR-886), a noncoding vault RNA that is transcribed by RNA polymerase III,, takes part in host cell regulation of PKR activity. Its two conformers bind to PKR and can either inhibit or weakly enhance PKR dimerization and activation (Lee et al, 2011; Jeon et al, 2012; Calderon & Conn, 2015). VTRNA2-1 activity has been implicated in pathological progress of oncogenesis (Lei J et al. 2017; Gao W et al. 2022) while several studies identified a tumor suppressive role of VTRNA2-1 (Fort RS et al. 2018, 2019; Yang R et al. 2021).
Literature References
PubMed ID Title Journal Year
34974812 Nc886 promotes renal cancer cell drug-resistance by enhancing EMT through Rock2 phosphorylation-mediated β-catenin nuclear translocation

Gao, W, Zhang, S, Guorong, L, Liu, Q, Zhu, A, Gui, F, Zou, Y, Wu, Y, Luo, Y, Hong, Z

Cell Cycle 2022
21518807 Precursor miR-886, a novel noncoding RNA repressed in cancer, associates with PKR and modulates its activity

Lee, K, Kunkeaw, N, Jeon, SH, Lee, I, Johnson, BH, Kang, GY, Bang, JY, Park, HS, Leelayuwat, C, Lee, YS

RNA 2011
32093270 vtRNA2-1/nc886 Produces a Small RNA That Contributes to Its Tumor Suppression Action through the microRNA Pathway in Prostate Cancer

Fort, RS, Garat, B, Sotelo-Silveira, JR, Duhagon, MA

Noncoding RNA 2020
28765891 Non-coding RNA 886 promotes renal cell carcinoma growth and metastasis through the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway

Lei, J, Xiao, JH, Zhang, SH, Liu, ZQ, Huang, K, Luo, ZP, Xiao, XL, Hong, ZD

Mol Med Rep 2017
29394925 Nc886 is epigenetically repressed in prostate cancer and acts as a tumor suppressor through the inhibition of cell growth

Fort, RS, Mathó, C, Geraldo, MV, Ottati, MC, Yamashita, AS, Saito, KC, Leite, KRM, Méndez, M, Maedo, N, Méndez, L, Garat, B, Kimura, ET, Sotelo-Silveira, JR, Duhagon, MA

BMC Cancer 2018
35685460 Downregulation of nc886 contributes to prostate cancer cell invasion and TGFβ1-induced EMT

Yang, R, Zuo, L, Ma, H, Zhou, Y, Zhou, P, Wang, L, Wang, M, Latif, M, Kong, L

Genes Dis 2022
22986343 Characterization of the direct physical interaction of nc886, a cellular non-coding RNA, and PKR

Jeon, SH, Lee, K, Lee, KS, Kunkeaw, N, Johnson, BH, Holthauzen, LM, Gong, B, Leelayuwat, C, Lee, YS

FEBS Lett 2012
28069888 Human noncoding RNA 886 (nc886) adopts two structurally distinct conformers that are functionally opposing regulators of PKR

Calderon, BM, Conn, GL

RNA 2017
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Authored
Stephan, R  (2023-05-15)
Reviewed
Patel, RC  (2023-08-16)
Created
Stephan, R  (2023-05-22)
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