Reactome | FA core complex:HSP70s binds PKR

FA core complex:HSP70s binds PKR

Stable Identifier

R-HSA-9835411

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Fanconi anemia group C protein (FANCC), as part of a complex of the Fanconi anemia core complex with HSP70 proteins, binds to PKR inhibiting its activation (Pang et al, 2001a; Pang et al, 2001b; Pang et al, 2002). PKR is constitutively activated in cells with mutations in the Fanconi anemia genes FANCA, FANCC, and FANCG, leading to hypersensitivity of bone marrow progenitor cells to growth repression and cell death (Zhang et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
11500375	FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity Pang, Q, Keeble, W, Christianson, TA, Faulkner, GR, Bagby, GC	EMBO J	2001
11238103	Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of Fanconi anemia complementation group C cells to interferon gamma, tumor necrosis factor-alpha, and double-stranded RNA Pang, Q, Keeble, W, Diaz, J, Christianson, TA, Fagerlie, S, Rathbun, K, Faulkner, GR, O'Dwyer, M, Bagby, GC	Blood	2001
15299030	The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR) Zhang, X, Li, J, Sejas, DP, Rathbun, KR, Bagby, GC, Pang, Q	J Biol Chem	2004
12397061	The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC Pang, Q, Christianson, TA, Keeble, W, Koretsky, T, Bagby, GC	J Biol Chem	2002