NCK1 binds PKR

Stable Identifier
R-HSA-9835189
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NCK1 binds PKR
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NCK1 binds to inactive protein kinase R (PKR, EIF2AK2) and prevents its activation, limiting the signaling induced by dsRNA. The mechanism of this process is unclear, however (Cardin & Larose, 2008).
Literature References
PubMed ID Title Journal Year
18835251 Nck-1 interacts with PKR and modulates its activation by dsRNA

Cardin, E, Larose, L

Biochem Biophys Res Commun 2008
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Orthologous Events
NCK1 binds PKR (Bos taurus)
NCK1 binds PKR (Caenorhabditis elegans)
NCK1 binds PKR (Canis familiaris)
NCK1 binds PKR (Danio rerio)
NCK1 binds PKR (Drosophila melanogaster)
NCK1 binds PKR (Mus musculus)
NCK1 binds PKR (Rattus norvegicus)
NCK1 binds PKR (Sus scrofa)
NCK1 binds PKR (Xenopus tropicalis)
Authored
Stephan, R  (2023-05-11)
Reviewed
Patel, RC  (2023-08-16)
Created
Stephan, R  (2023-05-12)
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