NS1 (1C) binds to MAVS

Stable Identifier
R-HSA-9833248
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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NS1 (1C) binds to MAVS
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hRSV nonstructural protein 1C (NS1) associates with mitochondria and mitochondrial antiviral signaling protein (MAVS, IPS-1). This disrupts the interaction between MAVS and antiviral innate immune response receptor RIG-I (also known as retinoic acid-inducible gene I protein RIG-1 or DExD/H-box helicase 58, DDX58), preventing the formation of the MAVS signalosome complex containing DDX58 or IFIH1, MAVS, TRAF3, and TBK1/IKBKE. NS1 is known to down-regulate interferon (IFN) production and to decrease activation of IFN-related signaling pathways (Boyapalle et al, 2012).
Literature References
PubMed ID Title Journal Year
22383950 Respiratory syncytial virus NS1 protein colocalizes with mitochondrial antiviral signaling protein MAVS following infection

Boyapalle, S, Wong, T, Garay, J, Teng, M, San Juan-Vergara, H, Mohapatra, S, Mohapatra, S

PLoS One 2012
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as an event of
Disease
Cross References
Mondo
Authored
Stephan, R  (2023-04-15)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Stephan, R  (2023-04-15)
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