SOX2 binds the ZEB2 gene

Stable Identifier
R-HSA-9833066
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SOX2 binds the SIP1 gene
ReviewStatus
5/5
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SOX2 binds the ZEB2 gene
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SOX2, POU5F1, NANOG, and SMAD2,3 bind the promoter of the ZEB2 (SIP1) gene about 6 kb upstream of the initiation codon of the ZEB2 coding region (Chng et al. 2010). Whereas POU5F1 and NANOG repress expression of ZEB2, SOX2 enhances expression (Chng et al. 2010). SMAD2,3 are activated by NODAL and repress expression of ZEB2 (Chng et al. 2010). ZEB2 directly activates several genes expressed in neuroectoderm (Chng et al. 2010).
Literature References
PubMed ID Title Journal Year
20074535 SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells

Pedersen, RA, Chng, Z, Vallier, L, Teo, A

Cell Stem Cell 2010
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Authored
May, B  (2023-04-12)
Reviewed
Kondoh, H  (2023-07-12)
Created
May, B  (2023-04-13)
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