Reactome | KIF5A [cytosol]

KIF5A [cytosol]

Stable Identifier

R-HSA-983190

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Neuronal kinesin heavy chain, Kinesin heavy chain isoform 5A, KIF5A_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate KTN1 (Homo sapiens)
        
        KTN1 binds Kinesin-1 (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        Kinesin-1 heavy chain [cytosol] (Homo sapiens)
        
        KIF5A [cytosol] (Homo sapiens)
        
        RHOA,RHOG,RAC1,CDC42:GTP:KTN1:Kinesin-1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        Kinesin-1 heavy chain [cytosol] (Homo sapiens)
        
        KIF5A [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        Kinesin-1 heavy chain [cytosol] (Homo sapiens)
        
        KIF5A [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        Kinesin-1 heavy chain [cytosol] (Homo sapiens)
        
        KIF5A [cytosol] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        Kinesin-1 heavy chain [cytosol] (Homo sapiens)
        
        KIF5A [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        Kinesin-1 heavy chain [cytosol] (Homo sapiens)
        
        KIF5A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12840 KIF5A

Gene Names

KIF5A, NKHC1

Chain

initiator methionine:, chain:2-1032

Reference Genes

BioGPS Gene:3798 KIF5A

COSMIC (genes):KIF5A KIF5A

CTD Gene:3798 KIF5A

dbSNP Gene:3798 KIF5A

ENSEMBL:ENSG00000155980 KIF5A

ENSEMBL_homo_sapiens_GENE:ENSG00000155980.13 KIF5A

HGNC:6323 KIF5A

KEGG Gene (Homo sapiens):3798 KIF5A

Monarch:3798 KIF5A

NCBI Gene:3798 KIF5A

OMIM:602821 KIF5A

UCSC:Q12840 KIF5A

Reference Transcript

RefSeq:NM_004984.2 KIF5A

Other Identifiers

11727398_a_at

11750595_a_at

11758975_s_at

11758976_at

16752995

205318_PM_at

205318_at

223933_PM_at

223933_at

3418250

3418251

3418254

3418255

3418256

3418257

3418259

3418260

3418261

3418262

3418263

3418264

3418266

3418267

3418268

3418271

3418272

3418273

3418276

3418277

3418278

3418279

3418280

3418281

3418282

3418283

3418285

3418286

3418287

3418289

3418291

3418292

3418293

3418297

3418299

3418300

3418302

35880_at

3798

49223_s_at

7956488

7956522

A_23_P218025

A_24_P227375

A_24_P93948

GE63027

GE83459

GO:0000166

GO:0003774

GO:0003777

GO:0003824

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005856

GO:0005871

GO:0005874

GO:0005929

GO:0006886

GO:0007018

GO:0007268

GO:0007411

GO:0008017

GO:0008092

GO:0008574

GO:0016020

GO:0016192

GO:0016787

GO:0016887

GO:0019894

GO:0023052

GO:0030154

GO:0032839

GO:0035253

GO:0043005

GO:0043025

GO:0043204

GO:0043226

GO:0045202

GO:0048471

GO:0048489

GO:0048856

GO:0098971

GO:0099641

GO:0140657

GO:1904115

GO:1990049

HMNXSV003005247

HMNXSV003028261

ILMN_1812254

ILMN_2227120

PH_hs_0025492

TC12000534.hg

TC12002400.hg

U06698_at

g12002045_3p_at

g4826807_3p_at

Participates

as a candidate of

KIF5B-like proteins [cytosol] (Homo sapiens)

as a member of

Kinesin-1 heavy chain [cytosol] (Homo sapiens)

Inferred To

KIF5A [cytosol] (Bos taurus)

KIF5A [cytosol] (Caenorhabditis elegans)

KIF5A [cytosol] (Canis familiaris)

KIF5A [cytosol] (Drosophila melanogaster)

KIF5A [cytosol] (Mus musculus)

KIF5A [cytosol] (Rattus norvegicus)

KIF5A [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_004975.2

OpenTargets

ENSG00000155980

HPA

ENSG00000155980-KIF5A

GeneCards

Q12840

Ensembl

ENST00000455537, ENSP00000408979, ENSG00000155980

ZINC target

Q12840

PRO

Q12840

Pharos - Targets

Q12840

Orphanet

16306

PDB

4UXT, 4UXY, 4UY0

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.553	2

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