Expression of PAX2 in the nephric duct

Stable Identifier
R-HSA-9830435
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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Expression of PAX2 in the nephric duct
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PAX2 is initially expressed in the intermediate mesoderm prior to renal specification and then continues expression in renal progenitors (inferred from mouse embryos in Bouchard et al. 2002, Boualia et al. 2011, Marcotte et al. 2014). In mouse embryos after initiation of the nephric duct, Pax2 activates expression of Lhx1, which activates expression of Emx2 (Marcotte et al. 2014). Emx2, in turn maintains expression of Pax2 in the developing nephric duct (Miyamoto et al. 1997). In mice, absence of Pax2 causes a failure to form mesonephric tubules (Torres et al. 1995)
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
EMX2 [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Pax2 in the nephric duct (Mus musculus)
Authored
May, B  (2023-03-10)
Created
May, B  (2023-03-12)
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