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Expression of WFDC2 in the nephric duct
Stable Identifier
R-HSA-9830365
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
extracellular region
ReviewStatus
3/5
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Developmental Biology (Homo sapiens)
Kidney development (Homo sapiens)
Formation of the nephric duct (Homo sapiens)
Expression of WFDC2 in the nephric duct (Homo sapiens)
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WFDC2 (also called HE4) is strongly expressed in the developing nephric duct (inferred from the mouse homolog in Boualia et al. 2013, inferred from the chicken homolog in Hellstrom et al. 2003). PAX2 activates expression of WFDC2 in nephric duct (inferred from mouse homologs in Boualia et al. 2013). Expression of Wfdc2 is completely lost in mouse embryos homozygous null for Pax2 and heterozygous null for Pax8 (Boualia et al. 2013). WFDC2 is able to regulate EGFR signaling, can downregulate expression of SNAI1 (Snail), CDH2 (N-Cadherin), and Vimentin, and can upregulate expression of CDH1 (E-Cadherin) (Xiong et al. 2020).
Participants
Input
WFDC2 gene [nucleoplasm]
(Homo sapiens)
Output
WFDC2 [extracellular region]
(Homo sapiens)
Participates
as an event of
Formation of the nephric duct (Homo sapiens)
This event is regulated
Positively by
Regulator
PAX2 [nucleoplasm]
(Homo sapiens)
Inferred From
Expression of Wfdc2 in the nephric duct (Mus musculus)
Authored
May, B (2023-03-08)
Created
May, B (2023-03-09)
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