SMAD2,3 and GATA6-AS1 lncRNA bind the GATA6 gene

Stable Identifier
R-HSA-9823959
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SMAD2,3 and GATA6-AS1 lncRNA bind the GATA6 gene
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NODAL signaling in the anterior primitive streak causes phosphorylation of SMAD2 and SMAD3 which co-translocate with SMAD4 to the nucleus and together bind the promoter of the GATA6 gene (inferred from human pluripotent stem cells in Brown et al. 2011, Yang et al. 2020). The antisense transcript GATA6-AS1 from an upstream region of the GATA6 coding region enhances the interaction between SMAD2,3 and the GATA6 promoter (Yang et al. 2020). GATA6-AS1 is required for differentiation of definitive endoderm from embryonic stem cells (Yang et al. 2020).
Literature References
PubMed ID Title Journal Year
21630377 Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

Dunn, NR, Lim, B, Cho, CH, Vallier, L, Pedersen, R, Hannan, N, Teo, A, Vardy, L, Brown, S, Trotter, M, Pauklin, S

Stem Cells 2011
32795420 GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation

Yan, C, Yang, J, Zhang, T, Li, M, Jiang, W, Lu, P

Stem Cell Reports 2020
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Authored
May, B  (2023-01-11)
Reviewed
Tam, PPL  (2023-02-28)
Salehin, N  (2023-02-28)
Created
May, B  (2023-01-13)
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