Reactome | TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

Stable Identifier

R-HSA-9823899

Type

Complex

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:TBK1

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
19656901	Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling Piao, W, Song, C, Chen, H, Diaz, MA, Wahl, LM, Fitzgerald, KA, Li, L, Medvedev, AE	J. Leukoc. Biol.	2009
17823124	Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF Gatot, JS, Gioia, R, Chau, TL, Patrascu, F, Warnier, M, Close, P, Chapelle, JP, Muraille, E, Brown, K, Siebenlist, U, Piette, J, Dejardin, E, Chariot, A	J. Biol. Chem.	2007
14530355	Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling Sato, S, Sugiyama, M, Yamamoto, M, Watanabe, Y, Kawai, T, Takeda, K, Akira, S	J. Immunol.	2003

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