KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3)

Stable Identifier
R-HSA-9822914
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3)
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KDM6B demethylates histone H3 trimethyllysine-27 (H3K27me3, lysine-28 of the preprotein) to yield histone H3 monomethyllysine-27 (H3K27me1) (Agger et al. 2007, Hong et al. 2007, Lan et al. 2007, and inferred from the mouse homolog). KDM6B is associated with loss of H3K27me3 in cleavage stage mouse embryos (Yang et al. 2016) and is required for loss of H3K27me3 in cleavage stage bovine embryos (Canovas et al. 2012).
Literature References
PubMed ID Title Journal Year
17851529 A histone H3 lysine 27 demethylase regulates animal posterior development

Lan, F, Bayliss, PE, Rinn, JL, Whetstine, JR, Wang, JK, Chen, S, Iwase, S, Alpatov, R, Issaeva, I, Canaani, E, Roberts, TM, Chang, HY, Shi, Y

Nature 2007
18003914 Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases

Hong, S, Cho, YW, Yu, LR, Yu, H, Veenstra, TD, Ge, K

Proc Natl Acad Sci U S A 2007
17713478 UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

Agger, K, Cloos, PA, Christensen, J, Pasini, D, Rose, S, Rappsilber, J, Issaeva, I, Canaani, E, Salcini, AE, Helin, K

Nature 2007
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Output
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Catalyst Activity

histone H3K27me2/H3K27me3 demethylase activity of KDM6B:Fe2+ [nucleoplasm]

Physical Entity
KDM6B:Fe2+ [nucleoplasm] (Homo sapiens)
Activity
histone H3K27me2/H3K27me3 demethylase activity (GO:0071558)
Inferred From
Kdm6b (Jmjd3) demethylates histone H3 trimethyllysine-27 (H3K27me3) (Mus musculus)
Authored
May, B  (2023-01-03)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2023-01-03)
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