AKAP8L binds MLL2 complex

Stable Identifier
R-HSA-9821366
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AKAP8L binds MLL2 complex
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AKAP8L (also known as AKAP95) binds to the MLL2 complex and increases its histone methyltransferase activity. The interaction with the MLL2 complex involves the N-terminus of AKAP8L. AKAP8L positively regulates transcription of several cellular differentiation-related genes (Jiang et al. 2013).
Literature References
PubMed ID Title Journal Year
23995757 Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95

Tang, Z, Roeder, RG, Jiang, H, Shimada, M, Dou, Y, Lu, X

Nat Struct Mol Biol 2013
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Orthologous Events
AKAP8L binds MLL2 complex (Bos taurus)
AKAP8L binds MLL2 complex (Mus musculus)
AKAP8L binds MLL2 complex (Rattus norvegicus)
AKAP8L binds MLL2 complex (Sus scrofa)
Authored
Orlic-Milacic, M  (2023-01-06)
Reviewed
Ge, K  (2023-02-08)
Van, H  (2023-02-08)
Created
Orlic-Milacic, M  (2022-12-02)
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