Reactome | Expression of ZSCAN4 in the embryo

Expression of ZSCAN4 in the embryo

Stable Identifier

R-HSA-9818523

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The ZSCAN4 gene, the single human homolog of the Zscan4 gene family in mouse, is transcribed to yield mRNA (Petropoulos et al. 2016) which is translated to yield protein. ZSCAN4 is expressed initially in 2-cell embryos (Yan et al. 2013), increases in 4-cell embryos (Yan et al. 2013), and continues in blastocysts (Petropoulos et al. 2016). DUX4 (Hendrickson et al. 2017) and TPRXL, TPRX1, and TPRX2 (Zou et al. 2022) directly activate ZSCAN4 during minor (initial) zygotic genome activation. ZSCAN4 binds nucleosomes of microsatellites and protects against DNA damage (inferred from the mouse homolog in Srinivasan et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
28459457	Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons Hendrickson, PG, Doráis, JA, Grow, EJ, Whiddon, JL, Lim, JW, Wike, CL, Weaver, BD, Pflueger, C, Emery, BR, Wilcox, AL, Nix, DA, Peterson, CM, Tapscott, SJ, Carrell, DT, Cairns, BR	Nat Genet	2017
27062923	Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos Petropoulos, S, Edsgärd, D, Reinius, B, Deng, Q, Panula, SP, Codeluppi, S, Plaza Reyes, A, Linnarsson, S, Sandberg, R, Lanner, F	Cell	2016
36074823	Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation Zou, Z, Zhang, C, Wang, Q, Hou, Z, Xiong, Z, Kong, F, Wang, Q, Song, J, Liu, B, Liu, B, Wang, L, Lai, F, Fan, Q, Tao, W, Zhao, S, Ma, X, Li, M, Wu, K, Zhao, H, Chen, ZJ, Xie, W	Science	2022
23934149	Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells Yan, L, Yang, M, Guo, H, Yang, L, Wu, J, Li, R, Liu, P, Lian, Y, Zheng, X, Yan, J, Huang, J, Li, M, Wu, X, Wen, L, Lao, K, Li, R, Qiao, J, Tang, F	Nat Struct Mol Biol	2013