Reactome | CD55 (DAF) binds C3bBb, C4bC2a

CD55 (DAF) binds C3bBb, C4bC2a

Stable Identifier

R-HSA-981535

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Decay-accelerating-factor (DAF, CD55) is a membrane- bound complement regulatory protein that inhibits autologous complement cascade activation. It is expressed on all cells that are in close contact with serum complement proteins, but also on cells outside the vascular space and on tumour cells. DAF binds to C3bBb and C4bC2a on cell surfaces, accelerating their dissociation and thereby inhibiting the amplification of complement. DAF can bind C3b and Bb, and must bind both for efficient decay acceleration. Although it can bind the inactive proenzymes C3b and C4b, the regulatory function of DAF is believed to be inhibition of activated C3 convertase enzymes (Harris et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17182573	Decay-accelerating factor must bind both components of the complement alternative pathway C3 convertase to mediate efficient decay Harris, CL, Pettigrew, DM, Lea, SM, Morgan, BP	J Immunol	2007
11694537	Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb Hourcade, DE, Mitchell, L, Kuttner-Kondo, LA, Atkinson, JP, Medof, ME	J Biol Chem	2002
2420889	Endogenous association of decay-accelerating factor (DAF) with C4b and C3b on cell membranes Kinoshita, T, Medof, ME, Nussenzweig, V	J Immunol	1986