Reactome | SLC22A1 transports Cipro into hepatic cell

SLC22A1 transports Cipro into hepatic cell

Stable Identifier

R-HSA-9795207

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, basolateral plasma membrane, cytosol

ReviewStatus

5/5

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SLC22A1 transports Cipro into hepatic cell

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Facilitated transport of Cipro through the basolateral parts of the hepatocyte membrane is the most probable mechanism by which Cipro enters hepatic cells (reviewed by Jetter & Kullak-Ublick, 2019). Transport of drugs by solute carrier family 22 member 1 (SLC22A1, OCT1), highly expressed in liver, is inhibited by most fluoroquinolones including Cipro (Mulgaonkar et al, 2013). Direct binding of Cipro to SLC22A1 or its role as substrate has not been shown, however.

Literature References

PubMed ID	Title	Journal	Year
23545524	Human organic cation transporters 1 (SLC22A1), 2 (SLC22A2), and 3 (SLC22A3) as disposition pathways for fluoroquinolone antimicrobials Mulgaonkar, A, Venitz, J, Gründemann, D, Sweet, DH	Antimicrob Agents Chemother	2013
31004787	Drugs and hepatic transporters: A review Jetter, A, Kullak-Ublick, GA	Pharmacol Res	2020