ABCG2 transports Cipro from hepatic cell to extracellular space

Stable Identifier
R-HSA-9794572
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region
ReviewStatus
5/5
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ABCG2 transports Cipro from hepatic cell to extracellular space
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Concentration of ciprofloxacin (Cipro) in bile is greater than in hepatic cells. ABCG2 is localized in the apical membrane of hepatic cells (Matsushima et al, 2005). ABCG2 transports Cipro to extracellular space which, in this reaction, is the bile duct lumen (Ando et al, 2007; reviewed by Alvarez et al, 2008).
Literature References
PubMed ID Title Journal Year
17639028 Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones

Ando, T, Kusuhara, H, Merino, G, Alvarez, AI, Schinkel, AH, Sugiyama, Y

Drug Metab Dispos 2007
15901800 Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein

Matsushima, S, Maeda, K, Kondo, C, Hirano, M, Sasaki, M, Suzuki, H, Sugiyama, Y

J Pharmacol Exp Ther 2005
18200507 Fluoroquinolone efflux mediated by ABC transporters

Alvarez, AI, Pérez, M, Prieto, JG, Molina, AJ, Real, R, Merino, G

J Pharm Sci 2008
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Output
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Catalyst Activity

ATPase-coupled transmembrane transporter activity of ABCG2 tetramer [apical plasma membrane ]

Physical Entity
ABCG2 tetramer [apical plasma membrane] (Homo sapiens)
Activity
ATPase-coupled transmembrane transporter activity (GO:0042626)
Orthologous Events
ABCG2 transports Cipro from hepatic cell to extracellular space (Bos taurus)
ABCG2 transports Cipro from hepatic cell to extracellular space (Caenorhabditis elegans)
ABCG2 transports Cipro from hepatic cell to extracellular space (Canis familiaris)
ABCG2 transports Cipro from hepatic cell to extracellular space (Dictyostelium discoideum)
ABCG2 transports Cipro from hepatic cell to extracellular space (Drosophila melanogaster)
ABCG2 transports Cipro from hepatic cell to extracellular space (Mus musculus)
ABCG2 transports Cipro from hepatic cell to extracellular space (Plasmodium falciparum)
ABCG2 transports Cipro from hepatic cell to extracellular space (Rattus norvegicus)
ABCG2 transports Cipro from hepatic cell to extracellular space (Sus scrofa)
ABCG2 transports Cipro from hepatic cell to extracellular space (Xenopus tropicalis)
Authored
Stephan, R  (2022-07-15)
Reviewed
Thorn, CF  (2022-11-09)
Created
Stephan, R  (2022-07-18)
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