Complement factor I binds to MCP, CR1:C4b, C3b

Stable Identifier
R-HSA-977602
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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Complement factor I binds to MCP, CR1:C4b, C3b
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Membrane cofactor protein (MCP, CD46) and Complement Receptor 1 (CR1) act as cofactors for the protease activity of complement factor I (CFI) which binds MCP or CR1 complexes with C3b or C4b, inactivating C3b/C4b.
Literature References
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Input
Output
Participates
as an event of
Orthologous Events
Complement factor I binds to MCP, CR1:C4b, C3b (Bos taurus)
Complement factor I binds to MCP, CR1:C4b, C3b (Canis familiaris)
Complement factor I binds to MCP, CR1:C4b, C3b (Mus musculus)
Complement factor I binds to MCP, CR1:C4b, C3b (Rattus norvegicus)
Complement factor I binds to MCP, CR1:C4b, C3b (Sus scrofa)
Authored
Jupe, S  (2010-10-26)
Reviewed
Bradley, DT  (2012-02-13)
Fraczek, LA  (2012-02-13)
Created
Jupe, S  (2010-10-20)
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