Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
PXLP-K305-HDC [cytosol]
Stable Identifier
R-HSA-977310
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
histidine decarboxylase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Histidine catabolism (Homo sapiens)
Histidine is decarboxylated to histamine (Homo sapiens)
PXLP-K305-HDC dimer [cytosol] (Homo sapiens)
PXLP-K305-HDC [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19113 HDC
Gene Names
HDC
Chain
chain:1-662
Reference Genes
BioGPS Gene:3067 HDC
COSMIC (genes):HDC HDC
CTD Gene:3067 HDC
dbSNP Gene:3067 HDC
ENSEMBL:ENSG00000140287.11 HDC
HGNC:4855 HDC
KEGG Gene (Homo sapiens):3067 HDC
Monarch:3067 HDC
NCBI Gene:3067 HDC
OMIM:142704 HDC
UCSC:P19113 HDC
Reference Transcript
RefSeq:NM_001306146.1 HDC
RefSeq:NM_002112.3 HDC
Other Identifiers
11755386_a_at
16809075
207067_PM_s_at
207067_s_at
3067
35606_at
3623656
3623657
3623658
3623659
3623660
3623662
3623667
3623668
3623670
3623671
3623672
3623674
3623676
3623677
3623679
7988672
A_23_P117662
D16583_at
GE81119
GO:0001694
GO:0003824
GO:0004398
GO:0005515
GO:0005737
GO:0005829
GO:0006520
GO:0006547
GO:0006548
GO:0016829
GO:0016830
GO:0016831
GO:0019752
GO:0030170
GO:0042423
HMNXSV003022594
ILMN_1792323
TC15001348.hg
g4504364_3p_a_at
Participates
as a component of
PXLP-K305-HDC dimer [cytosol] (Homo sapiens)
Inferred To
HDC [cytosol]
(Sus scrofa)
hdc [cytosol]
(Xenopus tropicalis)
PXLP-K305-HDC [cytosol]
(Bos taurus)
PXLP-K305-HDC [cytosol]
(Canis familiaris)
PXLP-K305-HDC [cytosol]
(Danio rerio)
PXLP-K305-HDC [cytosol]
(Drosophila melanogaster)
PXLP-K305-HDC [cytosol]
(Gallus gallus)
PXLP-K305-HDC [cytosol]
(Mus musculus)
PXLP-K305-HDC [cytosol]
(Rattus norvegicus)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 305
Coordinate
305
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
RefSeq
NP_001293075.1
,
NP_002103.2
Guide to Pharmacology - Targets
1274
OpenTargets
ENSG00000140287
IntEnz
4.1.1.22
HPA
ENSG00000140287-HDC
GeneCards
P19113
Ensembl
ENSP00000267845
,
ENSP00000440252
,
ENSG00000140287
,
ENST00000267845
,
ENST00000543581
PRO
P19113
Pharos - Targets
P19113
Orphanet
23008
HMDB Protein
HMDBP00885
PDB
7EIW
,
7EIX
,
7EIY
,
4E1O
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text