Reactome | SEMG1 [extracellular region]

SEMG1 [extracellular region]

Stable Identifier

R-HSA-977100

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Semenogelin-1, SEMG1_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Amyloid fiber formation (Homo sapiens)
  - Amyloid fibrils have additional components (Homo sapiens)
    - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
      - Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Semenogelin-1 amyloid fibril [extracellular region] (Homo sapiens)
        
        SEMG1 [extracellular region] (Homo sapiens)
    - Amyloid fibrils [plasma membrane] (Homo sapiens)
      - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Semenogelin-1 amyloid fibril [extracellular region] (Homo sapiens)
        
        SEMG1 [extracellular region] (Homo sapiens)
  - Amyloid precursor proteins form ordered fibrils (Homo sapiens)
    - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
      - Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Semenogelin-1 amyloid fibril [extracellular region] (Homo sapiens)
        
        SEMG1 [extracellular region] (Homo sapiens)
    - Amyloid fibril monomers [extracellular region] (Homo sapiens)
      - Localized amyloid fibril monomers [extracellular region] (Homo sapiens)
        
        SEMG1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04279 SEMG1

Gene Names

SEMG1, SEMG

Chain

signal peptide:1-23, chain:24-462, peptide:68-159, peptide:108-159, peptide:108-138

Reference Genes

BioGPS Gene:6406 SEMG1

COSMIC (genes):SEMG1 SEMG1

CTD Gene:6406 SEMG1

dbSNP Gene:6406 SEMG1

ENSEMBL:ENSG00000124233 SEMG1

HGNC:10742 SEMG1

KEGG:hsa:6406 SEMG1

Monarch:6406 SEMG1

NCBI Gene:6406 SEMG1

OMIM:182140 SEMG1

UCSC:P04279 SEMG1

Reference Transcript

RefSeq:NM_003007.5 SEMG1

Participates

as a member of

Localized amyloid fibril monomers [extracellular region] (Homo sapiens)

as a repeated unit of

Semenogelin-1 amyloid fibril [extracellular region] (Homo sapiens)

Other forms of this molecule

hC239-SEMG1 [extracellular region]

Cross References

RefSeq

NP_002998.1

ENSEMBL

ENST00000372781, ENSP00000361867, ENSG00000124233

OpenTargets

ENSG00000124233

GeneCards

SEMG1

HPA

ENSG00000124233-SEMG1

PRO

P04279

Pharos - Targets

P04279

PDB

7ZRF, 8BOO, 8BVZ, 7ZRO

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6N021 TET2	1	TET2 [nucleoplasm] (R-HSA-5221011)	0.589	2
UniProt:P26842 CD27	1	CD27 [plasma membrane] (R-HSA-5666994)	0.527	2

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