Spike Trimer Translocates to the Plasma Membrane

Stable Identifier
R-HSA-9769812
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane, plasma membrane
ReviewStatus
5/5
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Spike Trimer Translocates to the Plasma Membrane
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SARS-CoV-2 Spike protein (S) is present on the surface of infected cells (Buchrieser et al, 2021). During COPI (retrograde) transport from Golgi to the ERGIC, leakage of the S protein can occur from vesicles, due to inefficient binding of Spike to COPI. As a result, S appears to leak to the surface where it accumulates and can direct the formation of multinucleate syncytia. Additional results indicate that S is not efficiently endocytosed from the cell surface (Cattin-Ortolá et al, 2021).
Literature References
PubMed ID Title Journal Year
33051876 Syncytia formation by SARS-CoV-2-infected cells

Bruel, T, Guivel-Benhassine, F, Mouquet, H, Planas, D, Porrot, F, Rajah, MM, Buchrieser, J, Casartelli, N, van der Werf, S, Schwartz, O, Monel, B, Hubert, M, Dufloo, J, Planchais, C

EMBO J 2020
34504087 Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation

James, LC, Papa, G, Cattin-Ortolá, J, Maslen, SL, Munro, S, Welch, LG

Nat Commun 2021
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2022-03-22)
Reviewed
Gillespie, ME  (2022-05-10)
Created
Stephan, R  (2022-03-22)
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