Defects of Coagulation cascade

Stable Identifier
R-HSA-9769726
Type
Pathway
Species
Homo sapiens
ReviewStatus
3/5
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Defects of Coagulation cascade
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The Reactome module describes disorders that can cause abnormal bleeding due to a shortage (deficiency) of coagulation factor proteins, which are involved in blood clotting. This module also describes elevation of FIX, FV activities associated with thrombophilia. Genetic variants are named following Human Genome Variation Society (HGVS) nomenclature with sequence numbering starting from the first methionine of the protein as +1 (Goodeve AC et al.2011).
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
thrombosis DOID:0060903
thrombophilia DOID:2452 hypercoagulability state
factor VIII deficiency DOID:12134 Congenital factor VIII disorder, Subhemophilia, Hemophilia A
hemophilia B DOID:12259 factor IX deficiency, Congenital factor IX deficiency, deficiency, functional factor IX, Congenital factor IX disorder
Cross References
Mondo
Authored
Shamovsky, V  (2022-03-22)
Created
Shamovsky, V  (2022-03-22)
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