Activated glucocorticoid receptor represses NPAS4 gene transcription

Stable Identifier
R-HSA-9769345
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Activated glucocorticoid receptor represses NPAS4 gene transcription
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Based on studies in mouse neuronal cells, binding of agonist-activated glucocorticoid receptor NR3C1 (also known as GR) to evolutionarily conserved glucocorticoid response elements (GREs) upstream of the NPAS4 gene transcription start site represses NPAS4 gene transcription (Furukawa-Hibi et al. 2012). Chronic restraint stress as well as corticosterone injection reduce Npas4 gene expression in mouse hippocampus (Yun et al. 2010).
Participants
Input
Output
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as an event of
This event is regulated
Negatively by
Regulator
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer:NPAS4 gene [nucleoplasm] (Homo sapiens)
Active Unit
NR3C1:(ALDO,11DCORST,CORST,CORT) dimer [nucleoplasm]
Inferred From
Activated glucocorticoid receptor represses Npas4 gene transcription (Mus musculus)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-16)
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