ZEB2 binds SP1

Stable Identifier
R-HSA-9761027
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ZEB2 binds SP1
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ZEB2 (Zinc finger E-box-binding homeobox 2) forms a complex with the transcription factor SP1 (Nam et al. 2012) and increases the protein stability of SP1 by preventing its proteasome-mediated degradation (Nam et al. 2014).
Literature References
PubMed ID Title Journal Year
22227038 ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells

Nam, EH, Kim, S, Park, YK, Lee, Y, Lee, JW

Carcinogenesis 2012
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Orthologous Events
ZEB2 binds SP1 (Bos taurus)
ZEB2 binds SP1 (Canis familiaris)
ZEB2 binds SP1 (Danio rerio)
ZEB2 binds SP1 (Drosophila melanogaster)
ZEB2 binds SP1 (Gallus gallus)
ZEB2 binds SP1 (Mus musculus)
ZEB2 binds SP1 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2022-06-02)
Reviewed
Brasch, J  (2023-04-18)
Created
Orlic-Milacic, M  (2022-01-06)
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