CDH11 nascent mRNA is spliced into the variant splicing isoform

Stable Identifier
R-HSA-9759502
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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CDH11 nascent mRNA is spliced into the variant splicing isoform
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The CDH11 variant transcript consists of 14 exons. Compared to the canonical transcript, an extra exon of 179 nucleotides is spliced in between the canonical transcript's exons 12 and 13. This additional exon introduces a frameshift into the coding sequence of the CDH11 transmembrane domain, resulting in a shorter protein. Compared to the canonical CDH11 isoform, the variant CDH11 isoform lacks one third of the transmembrane domain and the entire cytoplasmic domain (Okazaki et al. 1994, Kawaguchi et al. 1999). Since the 3' UTR of the variant transcript remains identical to the 3' UTR of the canonical transcript, it can be assumed that CDH11-targeting miRNAs act against both splicing isoforms.
Literature References
PubMed ID Title Journal Year
8163513 Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts

Okazaki, M, Kikuno, R, Tsujimura, A, Amann, E, Takeshita, S, Kudo, A, Kawai, S

J Biol Chem 1994
10320525 Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11

Machinami, R, Takeshita, S, Kawaguchi, J, Kashima, T, Imai, T, Kudo, A

J Bone Miner Res 1999
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Authored
Orlic-Milacic, M  (2022-06-02)
Reviewed
Brasch, J  (2023-04-18)
Created
Orlic-Milacic, M  (2021-12-06)
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