LRAT esterifies RBP2:atROL and FACYLs to atREs

Stable Identifier
R-HSA-975608
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Transfer of fatty acyl residues (FACYLs) from lecithin is the main way to esterify all-trans-retinol (atROL). Lecithin is a generic name for the yellowy-brown fatty substances in animals and tissues. It can be composed of phosphatidylcholines, phosphatidylethanolamines, and phosphatidylinositols. Fatty acyl transfer is catalyzed by Lecithin retinol acyltransferase (LRAT) and takes place near the endoplasmic reticulum membrane. The main fatty acyl moieties that are substrates for LRAT are palmitoyl, oleoyl, stearoyl and linoleoyl groups present in the A1 position of membrane phosphatidylcholine molecules. LRAT esterifies atROL with these acyl groups to form all-trans-retinyl esters (atREs). The aim is not storage but transport via chylomicrons (Ruiz et al. 1999).

Literature References
PubMed ID Title Journal Year
16939223 Palmitoyl transferase activity of lecithin retinol acyl transferase

Xue, L, Jahng, WJ, Gollapalli, D, Rando, RR

Biochemistry 2006
9920938 Molecular and biochemical characterization of lecithin retinol acyltransferase.

Ruiz, A, Winston, A, Lim, YH, Gilbert, BA, Rando, RR, Bok, D

J Biol Chem 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylcholine-retinol O-acyltransferase activity of LRAT [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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