Reactome | LRAT esterifies RBP2:atROL and FACYLs to atREs

LRAT esterifies RBP2:atROL and FACYLs to atREs

Stable Identifier

R-HSA-975608

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane, plasma membrane

Synonyms

all-trans-retinol--(retinol-binding protein) + a 1,2-diacyl-sn-glycero-3-phosphocholine => apo--(retinol-binding protein) + an all-trans-retinyl ester + a 2-acyl-sn-glycero-3-phosphocholine

ReviewStatus

5/5

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LRAT esterifies RBP2:atROL and FACYLs to atREs

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Lecithin retinol acyltransferase (LRAT), associated with the endoplasmic reticulum mem-brane catalyzes the transfer of fatty acyl residues from phospholipids (annotated here as phosphatidylcholine, PC) in lecithin to all-trans-retinol (atROL), forming all-trans-retinyl esters (atREs). This reaction in enterocytes generates atREs that can be packaged into chylomicrons for transport (Ruiz et al. 1999; Xue et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
9920938	Molecular and biochemical characterization of lecithin retinol acyltransferase. Ruiz, A, Winston, A, Lim, YH, Gilbert, BA, Rando, RR, Bok, D	J Biol Chem	1999
16939223	Palmitoyl transferase activity of lecithin retinol acyl transferase Xue, L, Jahng, WJ, Gollapalli, D, Rando, RR	Biochemistry	2006