Reactome | LRAT esterifies RBP2:atROL and FACYLs to atREs

LRAT esterifies RBP2:atROL and FACYLs to atREs

Stable Identifier

R-HSA-975608

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane, plasma membrane

ReviewStatus

5/5

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LRAT esterifies RBP2:atROL and FACYLs to atREs

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Transfer of fatty acyl residues (FACYLs) from lecithin is the main way to esterify all-trans-retinol (atROL). Lecithin is a generic name for the yellowy-brown fatty substances in animals and tissues. It can be composed of phosphatidylcholines, phosphatidylethanolamines, and phosphatidylinositols. Fatty acyl transfer is catalyzed by Lecithin retinol acyltransferase (LRAT) and takes place near the endoplasmic reticulum membrane. The main fatty acyl moieties that are substrates for LRAT are palmitoyl, oleoyl, stearoyl and linoleoyl groups present in the A1 position of membrane phosphatidylcholine molecules. LRAT esterifies atROL with these acyl groups to form all-trans-retinyl esters (atREs). The aim is not storage but transport via chylomicrons (Ruiz et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
9920938	Molecular and biochemical characterization of lecithin retinol acyltransferase. Ruiz, A, Winston, A, Lim, YH, Gilbert, BA, Rando, RR, Bok, D	J Biol Chem	1999
16939223	Palmitoyl transferase activity of lecithin retinol acyl transferase Xue, L, Jahng, WJ, Gollapalli, D, Rando, RR	Biochemistry	2006