PNLIP:CLPS hydrolyses RPALM to atROL and PALM

Stable Identifier
R-HSA-975593
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
Digestion of retinyl palmitate by extracellular PTL:colipase
ReviewStatus
5/5
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PNLIP:CLPS hydrolyses RPALM to atROL and PALM
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Part of nutritional vitamin A is in the form of retinyl esters (REs). The main fatty acids which can form esters with retinol are palmitate, oleate, stearate and linoleate. REs are digested together with other lipids, and by the same enzymes. Pancreatic lipase catalyses the hydrolysis of RE to all-trans-retinol (atROL) and fatty acid which are then both taken up by enterocytic cell membranes (Bennekum et al. 2000).
Literature References
PubMed ID Title Journal Year
10769148 Hydrolysis of retinyl esters by pancreatic triglyceride lipase

Fisher, EA, Harrison, EH, van Bennekum, AM, Blaner, WS

Biochemistry 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

retinyl-palmitate esterase activity of PNLIP:CLPS [extracellular region]

Physical Entity
PNLIP:CLPS [extracellular region] (Homo sapiens)
Activity
retinyl-palmitate esterase activity (GO:0050253)
Orthologous Events
PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Bos taurus)
PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Gallus gallus)
PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Mus musculus)
PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Rattus norvegicus)
PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Sus scrofa)
PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Xenopus tropicalis)
Cross References
Rhea
Authored
Stephan, R  (2010-09-19)
Reviewed
D'Eustachio, P  (2010-11-09)
Created
Jassal, B  (2010-10-01)
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