Reactome | GABRQ [plasma membrane]

GABRQ [plasma membrane]

Stable Identifier

R-HSA-975504

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Gamma-aminobutyric acid receptor subunit theta, GBRT_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRQ [plasma membrane] (Homo sapiens)
      - NPTN binds GABA A receptors (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRQ [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers:GABA:NPTN [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRQ [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by ERBB4 (Homo sapiens)
    - NRG2-activated ERBB4 binds GABA receptors through GABRA1 (Homo sapiens)
      - GABRA1 heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABRA1 heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA1:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRQ [plasma membrane] (Homo sapiens)
      - NRG2:p-ERBB4 homodimers:GABRA1 heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABRA1 heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABRA1 heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA1:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRQ [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UN88 GABRQ

Gene Names

GABRQ

Chain

signal peptide:1-21, chain:22-632

Reference Genes

BioGPS Gene:55879 GABRQ

COSMIC (genes):GABRQ GABRQ

CTD Gene:55879 GABRQ

dbSNP Gene:55879 GABRQ

ENSEMBL:ENSG00000268089 GABRQ

ENSEMBL_homo_sapiens_GENE:ENSG00000268089.3 GABRQ

HGNC:14454 GABRQ

KEGG Gene (Homo sapiens):55879 GABRQ

Monarch:55879 GABRQ

NCBI Gene:55879 GABRQ

OMIM:300349 GABRQ

UCSC:Q9UN88 GABRQ

Reference Transcript

RefSeq:NM_018558.3 GABRQ

Other Identifiers

11738116_a_at

17107855

220886_PM_at

220886_at

238123_PM_at

238123_at

3995255

3995256

3995257

3995259

3995260

3995261

3995262

3995264

3995265

3995266

3995268

3995269

3995270

3995271

3995272

3995273

3995275

3995276

3995278

47299_at

55879

8170538

A_23_P125475

A_24_P367410

A_32_P115840

GE814210

GE82408

GO:0004888

GO:0004890

GO:0005215

GO:0005216

GO:0005230

GO:0005254

GO:0005326

GO:0005515

GO:0005886

GO:0006811

GO:0006821

GO:0006836

GO:0007165

GO:0016020

GO:0023052

GO:0030594

GO:0034220

GO:0034707

GO:0043005

GO:0043235

GO:0045202

GO:0045211

GO:0055085

GO:0060089

GO:1902476

GO:1902711

HMNXSV003043701

Hs.56147.0.A1_3p_at

ILMN_1793523

ILMN_1906362

PH_hs_0003662

PH_hs_0014598

TC0X000738.hg

U47334_at

g8924257_3p_at

g8924257_3p_s_at

Participates

as a component of

Inferred To

GABRB4 [plasma membrane] (Gallus gallus)

LOC100496398 [plasma membrane] (Xenopus tropicalis)

exp-1 [plasma membrane] (Caenorhabditis elegans)

lgc-35 [plasma membrane] (Caenorhabditis elegans)

Homologues of GABRQ [plasma membrane] (Caenorhabditis elegans)

Homologues of GABRQ [plasma membrane] (Drosophila melanogaster)

Rdl [plasma membrane] (Drosophila melanogaster)

Lcch3 [plasma membrane] (Drosophila melanogaster)

unc-49 [plasma membrane] (Caenorhabditis elegans)

lgc-38 [plasma membrane] (Caenorhabditis elegans)

lgc-43 [plasma membrane] (Caenorhabditis elegans)

GABRQ [plasma membrane] (Bos taurus)

GABRQ [plasma membrane] (Canis familiaris)

GABRQ [plasma membrane] (Sus scrofa)

Gabrq [plasma membrane] (Mus musculus)

Gabrq [plasma membrane] (Rattus norvegicus)

gab-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_061028.3

Guide to Pharmacology - Targets

418

OpenTargets

ENSG00000268089

HPA

ENSG00000268089-GABRQ

GeneCards

Q9UN88

Ensembl

ENSP00000469332, ENSG00000268089, ENST00000598523

PRO

Q9UN88

Pharos - Targets

Q9UN88

Orphanet

28463

HMDB Protein

HMDBP08215