Reactome | GABRR2 [plasma membrane]

GABRR2 [plasma membrane]

Stable Identifier

R-HSA-975444

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Gamma-aminobutyric acid receptor subunit rho-2, GBRR2_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABRR pentamers:GABA transports extracellular Cl- to cytosol (Homo sapiens)
        
        GABRR pentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABRR pentamers [plasma membrane] (Homo sapiens)
        
        GABRR2 pentamer [plasma membrane] (Homo sapiens)
        
        GABRR2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P28476 GABRR2

Gene Names

GABRR2

Chain

signal peptide:1-20, chain:21-465

Reference Genes

BioGPS Gene:2570 GABRR2

COSMIC (genes):GABRR2 GABRR2

CTD Gene:2570 GABRR2

dbSNP Gene:2570 GABRR2

ENSEMBL:ENSG00000111886 GABRR2

HGNC:4091 GABRR2

KEGG:hsa:2570 GABRR2

Monarch:2570 GABRR2

NCBI Gene:2570 GABRR2

OMIM:137162 GABRR2

UCSC:P28476 GABRR2

Reference Transcript

RefSeq:NM_002043.4 GABRR2

Other Identifiers

11748595_a_at

17021573

208217_PM_at

208217_at

2570

2964134

2964136

2964138

2964140

2964141

2964142

2964143

2964144

2964146

2964150

2964151

2964153

2964154

2964155

2964156

2964171

2964181

2964182

2964183

2964184

2964185

31551_at

8128099

GE561327

GO:0004888

GO:0004890

GO:0005215

GO:0005216

GO:0005230

GO:0005254

GO:0005886

GO:0006811

GO:0006821

GO:0007165

GO:0007214

GO:0007268

GO:0007601

GO:0016020

GO:0019904

GO:0022851

GO:0023052

GO:0030594

GO:0034220

GO:0034707

GO:0043005

GO:0045202

GO:0045211

GO:0050877

GO:0055085

GO:0060078

GO:0060089

GO:0098982

GO:1902476

GO:1902495

GO:1902711

GO:1904315

HMNXSV003013818

ILMN_1676870

M86868_at

PH_hs_0005585

TC06001939.hg

g4503870_3p_at

Participates

as a component of

GABRR2 pentamer [plasma membrane] (Homo sapiens)

Inferred To

unc-49 [plasma membrane] (Caenorhabditis elegans)

exp-1 [plasma membrane] (Caenorhabditis elegans)

lgc-35 [plasma membrane] (Caenorhabditis elegans)

Rdl [plasma membrane] (Drosophila melanogaster)

lgc-38 [plasma membrane] (Caenorhabditis elegans)

Lcch3 [plasma membrane] (Drosophila melanogaster)

lgc-43 [plasma membrane] (Caenorhabditis elegans)

GABRR2 [plasma membrane] (Bos taurus)

GABRR2 [plasma membrane] (Canis familiaris)

GABRR2 [plasma membrane] (Gallus gallus)

GABRR2 [plasma membrane] (Mus musculus)

GABRR2 [plasma membrane] (Rattus norvegicus)

GABRR2 [plasma membrane] (Sus scrofa)

Homologues of GABRR2 [plasma membrane] (Caenorhabditis elegans)

Homologues of GABRR2 [plasma membrane] (Drosophila melanogaster)

gab-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

421

ENSEMBL

ENSP00000386029, ENSG00000111886, ENST00000402938

OpenTargets

ENSG00000111886

ZINC - Substances

GBRR2_HUMAN

ZINC - Biogenic

GBRR2_HUMAN

ZINC target

P28476

PRO

P28476

GlyGen

P28476

ZINC - Investigational

GBRR2_HUMAN

ZINC - Metabolites

GBRR2_HUMAN

GeneCards

GABRR2

HPA

ENSG00000111886-GABRR2

Pharos - Targets

P28476

ZINC - Predictions - Purchasable

GBRR2_HUMAN

HMDB Protein

HMDBP08213