Reactome | GABRB1 [plasma membrane]

GABRB1 [plasma membrane]

Stable Identifier

R-HSA-975293

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Gamma-aminobutyric acid receptor subunit beta-1, GBRB1_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRBs [plasma membrane] (Homo sapiens)
        
        GABRB1 [plasma membrane] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRBs [plasma membrane] (Homo sapiens)
        
        GABRB1 [plasma membrane] (Homo sapiens)
      - NPTN binds GABA A receptors (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRBs [plasma membrane] (Homo sapiens)
        
        GABRB1 [plasma membrane] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRBs [plasma membrane] (Homo sapiens)
        
        GABRB1 [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers:GABA:NPTN [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRBs [plasma membrane] (Homo sapiens)
        
        GABRB1 [plasma membrane] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRBs [plasma membrane] (Homo sapiens)
        
        GABRB1 [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by ERBB4 (Homo sapiens)
    - NRG2-activated ERBB4 binds GABA receptors through GABRA1 (Homo sapiens)
      - GABRA1 heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABRA1 heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA1:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRBs [plasma membrane] (Homo sapiens)
        
        GABRB1 [plasma membrane] (Homo sapiens)
        
        2GABRA1:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRBs [plasma membrane] (Homo sapiens)
        
        GABRB1 [plasma membrane] (Homo sapiens)
      - NRG2:p-ERBB4 homodimers:GABRA1 heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABRA1 heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABRA1 heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA1:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRBs [plasma membrane] (Homo sapiens)
        
        GABRB1 [plasma membrane] (Homo sapiens)
        
        2GABRA1:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRBs [plasma membrane] (Homo sapiens)
        
        GABRB1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P18505 GABRB1

Gene Names

GABRB1

Chain

signal peptide:1-25, chain:26-474

Reference Genes

BioGPS Gene:2560 GABRB1

COSMIC (genes):GABRB1 GABRB1

CTD Gene:2560 GABRB1

dbSNP Gene:2560 GABRB1

ENSEMBL:ENSG00000163288 GABRB1

ENSEMBL_homo_sapiens_GENE:ENSG00000163288.14 GABRB1

HGNC:4081 GABRB1

KEGG Gene (Homo sapiens):2560 GABRB1

Monarch:2560 GABRB1

NCBI Gene:2560 GABRB1

OMIM:137190 GABRB1

UCSC:P18505 GABRB1

Reference Transcript

RefSeq:NM_000812.3 GABRB1

Other Identifiers

11736306_a_at

16966497

207010_PM_at

207010_at

2560

2725978

2725979

2725980

2725981

2725982

2726004

2726020

2726021

2726036

2726037

2726038

2726039

2726042

2726043

2726044

2726045

2726046

2726047

35028_at

8094901

A_14_P108419

A_14_P121288

A_23_P125435

GE59717

GO:0004888

GO:0004890

GO:0005215

GO:0005216

GO:0005230

GO:0005253

GO:0005254

GO:0005634

GO:0005635

GO:0005886

GO:0006811

GO:0006821

GO:0007165

GO:0007214

GO:0009636

GO:0015276

GO:0016020

GO:0021954

GO:0022414

GO:0022851

GO:0023052

GO:0030154

GO:0030425

GO:0030594

GO:0032570

GO:0034220

GO:0034707

GO:0042698

GO:0043005

GO:0043226

GO:0043235

GO:0045202

GO:0045211

GO:0048787

GO:0048856

GO:0050811

GO:0055085

GO:0060078

GO:0060089

GO:0071420

GO:0097060

GO:0098656

GO:0098685

GO:0098982

GO:0099505

GO:0099507

GO:0099634

GO:0150047

GO:1902476

GO:1902711

GO:1904315

HMNXSV003002765

ILMN_2159730

M59216_s_at

PH_hs_0005018

TC04000273.hg

X14767_at

g12548775_3p_at

Participates

as a member of

GABRBs [plasma membrane] (Homo sapiens)

Inferred To

GABRB1 [plasma membrane] (Bos taurus)

GABRB1 [plasma membrane] (Canis familiaris)

GABRB1 [plasma membrane] (Mus musculus)

GABRB1 [plasma membrane] (Rattus norvegicus)

GABRB1 [plasma membrane] (Sus scrofa)

Lcch3 [plasma membrane] (Drosophila melanogaster)

gabrb1 [plasma membrane] (Xenopus tropicalis)

gab-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000803.2

Guide to Pharmacology - Targets

410

OpenTargets

ENSG00000163288

HPA

ENSG00000163288-GABRB1

GeneCards

P18505

Ensembl

ENSG00000163288, ENSP00000295454, ENST00000510909, ENSP00000426766, ENST00000295454

PRO

P18505

Pharos - Targets

P18505

Orphanet

24553

HMDB Protein

HMDBP08204