Reactome | GABRA1 [plasma membrane]

GABRA1 [plasma membrane]

Stable Identifier

R-HSA-975262

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Gamma-aminobutyric acid receptor subunit alpha-1, GBRA1_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA1 [plasma membrane] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA1 [plasma membrane] (Homo sapiens)
      - NPTN binds GABA A receptors (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA1 [plasma membrane] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA1 [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers:GABA:NPTN [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA1 [plasma membrane] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA1 [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by ERBB4 (Homo sapiens)
    - NRG2-activated ERBB4 binds GABA receptors through GABRA1 (Homo sapiens)
      - GABRA1 heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABRA1 heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA1:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRA1 [plasma membrane] (Homo sapiens)
        
        2GABRA1:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRA1 [plasma membrane] (Homo sapiens)
      - NRG2:p-ERBB4 homodimers:GABRA1 heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABRA1 heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABRA1 heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA1:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRA1 [plasma membrane] (Homo sapiens)
        
        2GABRA1:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRA1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14867 GABRA1

Gene Names

GABRA1

Chain

signal peptide:1-27, chain:28-456

Reference Genes

BioGPS Gene:2554 GABRA1

COSMIC (genes):GABRA1 GABRA1

CTD Gene:2554 GABRA1

dbSNP Gene:2554 GABRA1

ENSEMBL:ENSG00000022355 GABRA1

HGNC:4075 GABRA1

KEGG Gene (Homo sapiens):2554 GABRA1

Monarch:2554 GABRA1

NCBI Gene:2554 GABRA1

OMIM:137160 GABRA1

UCSC:P14867 GABRA1

Reference Transcript

Other Identifiers

0000730731

11733808_a_at

11741084_a_at

11741205_a_at

16991797

206678_at

244118_at

2554

2838429

2838430

2838431

2838432

2838433

2838434

2838435

2838436

2838438

2838439

2838441

2838442

2838443

2838444

2838445

2838447

2838449

2838451

2838452

2838453

2838454

36323_at

8109663

A_23_P125067

A_24_P226267

A_33_P3373388

GE58233

GO:0003674

GO:0004888

GO:0004890

GO:0005216

GO:0005230

GO:0005237

GO:0005254

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0005887

GO:0006810

GO:0006811

GO:0006821

GO:0007165

GO:0007214

GO:0007267

GO:0007268

GO:0008144

GO:0008150

GO:0008503

GO:0016020

GO:0016021

GO:0016917

GO:0022607

GO:0022851

GO:0022857

GO:0030054

GO:0030594

GO:0030659

GO:0031410

GO:0032590

GO:0032991

GO:0034220

GO:0034330

GO:0034707

GO:0042391

GO:0043005

GO:0043226

GO:0045202

GO:0045211

GO:0048856

GO:0050809

GO:0050877

GO:0051932

GO:0055085

GO:0060078

GO:0071420

GO:0098794

GO:0098982

GO:0099060

GO:1902476

GO:1902710

GO:1902711

GO:1904315

GO:1904862

HMNXSV003039447

Hs.167398.0.A1_3p_at

ILMN_1802633

PH_hs_0032004

TC05000903.hg

X14766_at

g4585862_3p_at

Participates

as a component of

as a member of

GABRAs [plasma membrane] (Homo sapiens)

Inferred To

lgc-55 [plasma membrane] (Caenorhabditis elegans)

exp-1 [plasma membrane] (Caenorhabditis elegans)

GABRA1 [plasma membrane] (Bos taurus)

GABRA1 [plasma membrane] (Canis familiaris)

GABRA1 [plasma membrane] (Gallus gallus)

GABRA1 [plasma membrane] (Sus scrofa)

GABRA1 [plasma membrane] (Xenopus tropicalis)

lgc-35 [plasma membrane] (Caenorhabditis elegans)

Gabra1 [plasma membrane] (Mus musculus)

Gabra1 [plasma membrane] (Rattus norvegicus)

Rdl [plasma membrane] (Drosophila melanogaster)

lgc-52 [plasma membrane] (Caenorhabditis elegans)

lgc-37 [plasma membrane] (Caenorhabditis elegans)

mod-1 [plasma membrane] (Caenorhabditis elegans)

lgc-38 [plasma membrane] (Caenorhabditis elegans)

Lcch-14A [plasma membrane] (Drosophila melanogaster)

gabra1 [plasma membrane] (Danio rerio)

Grd [plasma membrane] (Drosophila melanogaster)

lgc-48 [plasma membrane] (Caenorhabditis elegans)

acc-2 [plasma membrane] (Caenorhabditis elegans)

Homologues of GABRA1 [plasma membrane] (Caenorhabditis elegans)

Homologues of GABRA1 [plasma membrane] (Drosophila melanogaster)

lgc-49 [plasma membrane] (Caenorhabditis elegans)

lgc-54 [plasma membrane] (Caenorhabditis elegans)

acc-4 [plasma membrane] (Caenorhabditis elegans)

acc-1 [plasma membrane] (Caenorhabditis elegans)

ggr-3 [plasma membrane] (Caenorhabditis elegans)

lgc-51 [plasma membrane] (Caenorhabditis elegans)

lgc-47 [plasma membrane] (Caenorhabditis elegans)

unc-49 [plasma membrane] (Caenorhabditis elegans)

acc-3 [plasma membrane] (Caenorhabditis elegans)

lgc-53 [plasma membrane] (Caenorhabditis elegans)

lgc-46 [plasma membrane] (Caenorhabditis elegans)

lgc-36 [plasma membrane] (Caenorhabditis elegans)

lgc-50 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001121115.1, NP_001121117.1, NP_001121116.1, NP_001121120.1, NP_000797.2

ZINC - World Drugs

GBRA1_HUMAN

Guide to Pharmacology - Targets

404

OpenTargets

ENSG00000022355

ZINC - FDA approved

GBRA1_HUMAN

ZINC - Substances

GBRA1_HUMAN

ZINC target

P14867

PRO

P14867

GlyGen

P14867

PDB

6D1S, 6HUO, 6D6T, 6HUK, 6X3V, 6X3Z, 6X3U, 6I53, 6HUJ, 6X3T, 6X3X, 6HUG, 6X3S, 6D6U, 6X40, 6X3W, 6CDU, 6HUP

HPA

ENSG00000022355-GABRA1

GeneCards

P14867

Ensembl

ENSP00000023897, ENST00000437025, ENSG00000022355, ENST00000637827, ENST00000636573, ENSP00000393097, ENSP00000490320, ENST00000638112, ENSP00000490804, ENST00000635880, ENSP00000489839, ENSP00000377517, ENST00000023897, ENSP00000415441, ENST00000428797, ENST00000393943, ENSP00000489738

Pharos - Targets

P14867

Orphanet

16089

ZINC - Predictions - Purchasable

GBRA1_HUMAN

HMDB Protein

HMDBP08198