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IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
Stable Identifier
R-HSA-975183
Type
Complex
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1,
Influenza A virus,
Human SARS coronavirus,
Severe acute respiratory syndrome coronavirus 2
Compartment
endosome membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
20485341
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
Lo, YC
,
Lin, SC
,
Wu, H
Nature
2010
Participants
components
x 4
IRAK4 [endosome membrane]
(Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane]
(Homo sapiens)
Participates
as an output of
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
as an input of
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
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