UGT1A6 glucuronates ST

Stable Identifier
R-HSA-9749977
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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UGT1A6 glucuronates ST
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A side effect of phenolic glucuronidation of salicylate (ST) (resulting in the O-glucuronide) is acyl glucuronation. In particular UGT1A6 glucuronates ST preferentially at the carboxyl group (Hutt et al, 1986; Iyanagi, 2007; Kuehl et al, 2006).
Literature References
PubMed ID Title Journal Year
16258079 Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomes

Kuehl, GE, Bigler, J, Potter, JD, Lampe, JW

Drug Metab Dispos 2006
17482904 Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification

Iyanagi, T

Int Rev Cytol 2007
3705620 The metabolism of aspirin in man: a population study

Hutt, AJ, Caldwell, J, Smith, RL

Xenobiotica 1986
Participants
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Output
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as an event of
Catalyst Activity

glucuronosyltransferase activity of UGT1A6 [endoplasmic reticulum membrane]

Physical Entity
UGT1A6 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
glucuronosyltransferase activity (GO:0015020)
Orthologous Events
UGT1A6 glucuronates ST (Mus musculus)
UGT1A6 glucuronates ST (Rattus norvegicus)
Authored
Stephan, R  (2021-08-05)
Reviewed
Huddart, R  (2021-10-13)
Created
Stephan, R  (2021-08-09)
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