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p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm]
Stable Identifier
R-HSA-9736938
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
Degradation of SMAD2/3:SMAD4 complex (Homo sapiens)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
SMURF2 binds SMAD3 phosphorylated in the linker region (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
SMURF2 monoubiquitinates SMAD3 (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
Degradation of SMAD2/3:SMAD4 complex (Homo sapiens)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
SMURF2 binds SMAD3 phosphorylated in the linker region (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
SMURF2 monoubiquitinates SMAD3 (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Homo sapiens)
Participants
components
p-T179,S423,S425-SMAD3 [nucleoplasm]
(Homo sapiens)
p-T220,S465,S467-SMAD2 [nucleoplasm]
(Homo sapiens)
SMAD4 [nucleoplasm]
(Homo sapiens)
Participates
as a member of
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Homo sapiens)
Inferred To
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm]
(Bos taurus)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm]
(Caenorhabditis elegans)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm]
(Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm]
(Drosophila melanogaster)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm]
(Mus musculus)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm]
(Rattus norvegicus)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm]
(Sus scrofa)
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