NKX2-5 binds the GATA4 gene

Stable Identifier
R-HSA-9735143
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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NKX2-5 binds the GATA4 gene
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NKX2-5 binds sites (called NKE sites) in the promoter upstream of the first exon of GATA4 in embryonic hearts (Riazi et al. 2009). NKX2-5 enhances transcription of GATA4 (Riazi et al. 2009), which then directly enhances transcription of NKX2-5.
Literature References
PubMed ID Title Journal Year
19479054 NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes

Riazi, AM, Takeuchi, JK, Hornberger, LK, Zaidi, SH, Amini, F, Coles, J, Bruneau, BG, Van Arsdell, GS

PLoS One 2009
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Authored
May, B  (2021-06-18)
Created
May, B  (2021-06-21)
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