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ORC6 is phosphorylated on T195
Stable Identifier
R-HSA-9734687
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Assembly of the ORC complex at the origin of replication (Homo sapiens)
ORC6 is phosphorylated on T195 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ORC6 is phosphorylated on threonine residue 195 (T195), a CDK target site, by an unidentified CDK (Ghosh et al. 2011).
Literature References
PubMed ID
Title
Journal
Year
21555516
Assembly of the human origin recognition complex occurs through independent nuclear localization of its components
Ghosh, S
,
Zhao, Y
,
Vassilev, AP
,
Zhang, J
,
DePamphilis, ML
J Biol Chem
2011
Participants
Input
ATP [cytosol]
ORC6:KPNA1,KPNA6:KPNB1 [cytosol]
(Homo sapiens)
Output
ADP [cytosol]
p-T195-ORC6:KPNA1,KPNA6:KPNB1 [cytosol]
(Homo sapiens)
Participates
as an event of
Assembly of the ORC complex at the origin of replication (Homo sapiens)
Orthologous Events
ORC6 is phosphorylated on T195 (Bos taurus)
ORC6 is phosphorylated on T195 (Canis familiaris)
ORC6 is phosphorylated on T195 (Drosophila melanogaster)
ORC6 is phosphorylated on T195 (Gallus gallus)
ORC6 is phosphorylated on T195 (Mus musculus)
ORC6 is phosphorylated on T195 (Rattus norvegicus)
ORC6 is phosphorylated on T195 (Schizosaccharomyces pombe)
ORC6 is phosphorylated on T195 (Sus scrofa)
ORC6 is phosphorylated on T195 (Xenopus tropicalis)
Authored
Kusic-Tisma, J (2021-06-18)
Created
Orlic-Milacic, M (2021-06-18)
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