Reactome | p-S172-TBK1:p-S172-TBK1 [cytosol]

p-S172-TBK1:p-S172-TBK1 [cytosol]

Stable Identifier

R-HSA-9730457

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S172-TBK1 homodimer, activated TBK1 homodimer

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
        
        viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
23453972	Structure and ubiquitination-dependent activation of TANK-binding kinase 1 Tu, D, Zhu, Z, Zhou, AY, Yun, CH, Lee, KE, Toms, AV, Li, Y, Dunn, GP, Chan, E, Thai, T, Yang, S, Ficarro, SB, Marto, JA, Jeon, H, Hahn, WC, Barbie, DA, Eck, MJ	Cell Rep	2013

Participants

components

x 2 p-S172-TBK1 [cytosol] (Homo sapiens)

Participates

as a component of

as a member of

p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Homo sapiens)

Inferred To

p-S172-TBK1:p-S172-TBK1 [cytosol] (Bos taurus)

p-S172-TBK1:p-S172-TBK1 [cytosol] (Canis familiaris)

p-S172-TBK1:p-S172-TBK1 [cytosol] (Gallus gallus)

p-S172-TBK1:p-S172-TBK1 [cytosol] (Mus musculus)

p-S172-TBK1:p-S172-TBK1 [cytosol] (Rattus norvegicus)

p-S172-TBK1:p-S172-TBK1 [cytosol] (Sus scrofa)

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