SARS-CoV-2 3CLpro dimer cleaves NLRP12

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
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SARS-CoV-2 nsp5 protease (3CLpro) specifically cleaves NLRP12 at two sites and decreases its level in SARS-CoV-2 infected cells (Moustaqil et al, 2021). NLRP12 normally modulates the expression of inflammatory cytokines through the regulation of the NFκB and MAPK pathways (Wang et al, 2002). NLRP12 is also involved in adaptive immunity and controls MHC class I expression through a yet ill-defined mechanism (Williams et al, 2003).
Literature References
PubMed ID Title Journal Year
12759408 Cutting edge: Monarch-1: a pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes

Williams, KL, Ting, JP, Taxman, DJ, Linhoff, MW, Reed, W

J Immunol 2003
33372854 SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

Moustaqil, M, Jacques, D, Gambin, Y, Rudolffi-Soto, P, Freiberg, AN, Hunter, DJB, Chiu, HP, Bhumkar, A, Lee, B, Van Tol, S, Ollivier, E, Sierecki, E, Stevens, C

Emerg Microbes Infect 2021
12019269 PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

Manji, GA, Lora, JM, Wang, L, Al-Garawi, A, Merriam, S, Briskin, M, Grenier, JM, Bertin, J, DiStefano, PS, Geddes, BJ

J Biol Chem 2002
Catalyst Activity

cysteine-type endopeptidase activity of 3CLp dimer [cytosol]

Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
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