SARS-CoV-2 N binds to TRIM25

Stable Identifier
R-HSA-9729437
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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SARS-CoV-2 N binds to TRIM25
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Type I interferon (IFN-I) immune signaling is dampened in COVID-19, and SARS-CoV-2 nucleocapsid (N) protein produces this effect (Li et al, 2020). N co-localized and co-immunoprecipitated with TRIM25 (Gianni Gori Savellini et al. 2021; Oh & Shin 2021). Moreover, co-localization of RIG-I and TRIM25 was destroyed by co-expression of N protein. In summary, low-dose N protein suppressed IFN-I production via sequestering TRIM25 to inhibit RIG-I ubiquitination, while high-dose N protein promoted IFN-I signaling and inflammatory cytokine expression (Oh & Shin 2021; Zhao et al. 2021).
Literature References
PubMed ID Title Journal Year
34471099 A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response

Zhao, Y, Sui, L, Wu, P, Wang, W, Wang, Z, Yu, Y, Hou, Z, Tan, G, Liu, Q, Wang, G

Signal Transduct Target Ther 2021
33801464 SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response

Oh, SJ, Shin, OS

Cells 2021
34452305 SARS-CoV-2 N Protein Targets TRIM25-Mediated RIG-I Activation to Suppress Innate Immunity

Gori Savellini, G, Anichini, G, Gandolfo, C, Cusi, MG

Viruses 2021
32589897 The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

Li, JY, Liao, CH, Wang, Q, Tan, YJ, Luo, R, Qiu, Y, Ge, XY

Virus Res 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2021-05-03)
Reviewed
Messina, F  (2022-02-18)
Created
Stephan, R  (2021-04-28)
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