Bitter compound binds bitter taste receptor (TAS2R)

Stable Identifier
Reaction [binding]
Homo sapiens
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A bitter taste compound (tastant) binds a bitter taste receptor (TAS2R) (Meyerhof et al. 2010, Thalmann et al. 2013). The binding causes a conformational change in the TAS2R that is transmitted to an associated heterotrimeric G protein complex comprising GNAT3 (gustducin), GNB1 or GNB3, and GNG13. Particular TAS2Rs, such as TAS2R1, bind particular sets of bitter tastants (Meyerhof et al. 2010).

Literature References
PubMed ID Title Journal Year
10761935 T2Rs function as bitter taste receptors

Guo, W, Ryba, NJ, Chandrashekar, J, Zuker, CS, Hoon, MA, Mueller, KL, Feng, L, Adler, E

Cell 2000
23632330 Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol

Thalmann, S, Meyerhof, W, Behrens, M

Biochem Biophys Res Commun 2013
20022913 The molecular receptive ranges of human TAS2R bitter taste receptors

Appendino, G, Chudoba, E, Batram, C, Bufe, B, Kuhn, C, Meyerhof, W, Behrens, M, Brockhoff, A

Chem. Senses 2010
Orthologous Events
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