Reactome | Bitter compound binds bitter taste receptor (TAS2R)

Bitter compound binds bitter taste receptor (TAS2R)

Stable Identifier

R-HSA-9728748

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Bitter compound binds bitter taste receptor (TAS2R)

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A bitter taste compound (tastant) binds a bitter taste receptor (TAS2R) (Meyerhof et al. 2010, Thalmann et al. 2013). The binding causes a conformational change in the TAS2R that is transmitted to an associated heterotrimeric G protein complex comprising GNAT3 (gustducin), GNB1 or GNB3, and GNG13. Particular TAS2Rs, such as TAS2R1, bind particular sets of bitter tastants (Meyerhof et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
10761935	T2Rs function as bitter taste receptors Chandrashekar, J, Mueller, KL, Hoon, MA, Adler, E, Feng, L, Guo, W, Zuker, CS, Ryba, NJ	Cell	2000
23632330	Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol Thalmann, S, Behrens, M, Meyerhof, W	Biochem Biophys Res Commun	2013
20022913	The molecular receptive ranges of human TAS2R bitter taste receptors Meyerhof, W, Batram, C, Kuhn, C, Brockhoff, A, Chudoba, E, Bufe, B, Appendino, G, Behrens, M	Chem. Senses	2010