Reactome | Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3)

Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3)

Stable Identifier

R-HSA-9728723

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3)

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Sweet taste compounds (tastants) bind the sweet taste receptor, which is a heterodimer of TAS1R2 and TAS1R3 (Li et al. 2002, Liu et al. 2011, Bassoli et al. 2014, Maillet et al. 2015, Shim et al. 2015). The binding causes a conformational change in TAS1R2:TAS1R3 that is transmitted to an associated heterotrimeric G protein complex comprising GNAT3:GNB1,3:GNG13. Sweet tastants include sucrose, glucose, maltose, aspartame (Liu et al. 2011, Maillet et al. 2015), saccharin, and certain D amino acids such as D-tryptophan (Bassoli et al. 2014). Umami (savory) compounds such as L-glutamate inhibit sweet taste by preventing sweet tastants from binding TAS1R2 (Shim et al. 2015). Knockout of Tas1r3 in mice does not abolish the ability to taste sweet and umami compounds indicating that other pathways also exist to detect these compounds (Damak et al. 2003, Delay et al. 2006, Yasumatsu et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
26377607	Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor Maillet, EL, Cui, M, Jiang, P, Mezei, M, Hecht, E, Quijada, J, Margolskee, RF, Osman, R, Max, M	Chem Senses	2015
11917125	Human receptors for sweet and umami taste Li, X, Staszewski, L, Xu, H, Durick, K, Zoller, M, Adler, E	Proc Natl Acad Sci U S A	2002
24360415	The taste of D- and L-amino acids: In vitro binding assays with cloned human bitter (TAS2Rs) and sweet (TAS1R2/TAS1R3) receptors Bassoli, A, Borgonovo, G, Caremoli, F, Mancuso, G	Food Chem	2014
25853419	Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2 Shim, J, Son, HJ, Kim, Y, Kim, KH, Kim, JT, Moon, H, Kim, MJ, Misaka, T, Rhyu, MR	PLoS One	2015
21795555	Molecular mechanism of species-dependent sweet taste toward artificial sweeteners Liu, B, Ha, M, Meng, XY, Kaur, T, Khaleduzzaman, M, Zhang, Z, Jiang, P, Li, X, Cui, M	J Neurosci	2011