Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3)

Stable Identifier
R-HSA-9728723
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Sweet taste compounds (tastants) bind the sweet taste receptor, which is a heterodimer of TAS1R2 and TAS1R3 (Li et al. 2002, Liu et al. 2011, Bassoli et al. 2014, Maillet et al. 2015, Shim et al. 2015). The binding causes a conformational change in TAS1R2:TAS1R3 that is transmitted to an associated heterotrimeric G protein complex comprising GNAT3:GNB1,3:GNG13. Sweet tastants include sucrose, glucose, maltose, aspartame (Liu et al. 2011, Maillet et al. 2015), saccharin, and certain D amino acids such as D-tryptophan (Bassoli et al. 2014). Umami (savory) compounds such as L-glutamate inhibit sweet taste by preventing sweet tastants from binding TAS1R2 (Shim et al. 2015). Knockout of Tas1r3 in mice does not abolish the ability to taste sweet and umami compounds indicating that other pathways also exist to detect these compounds (Damak et al. 2003, Delay et al. 2006, Yasumatsu et al. 2009).

Literature References
PubMed ID Title Journal Year
11917125 Human receptors for sweet and umami taste

Li, X, Staszewski, L, Xu, H, Durick, K, Zoller, M, Adler, E

Proc Natl Acad Sci U S A 2002
26377607 Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor

Maillet, EL, Cui, M, Jiang, P, Mezei, M, Hecht, E, Quijada, J, Margolskee, RF, Osman, R, Max, M

Chem Senses 2015
24360415 The taste of D- and L-amino acids: In vitro binding assays with cloned human bitter (TAS2Rs) and sweet (TAS1R2/TAS1R3) receptors

Bassoli, A, Borgonovo, G, Caremoli, F, Mancuso, G

Food Chem 2014
25853419 Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2

Shim, J, Son, HJ, Kim, Y, Kim, KH, Kim, JT, Moon, H, Kim, MJ, Misaka, T, Rhyu, MR

PLoS One 2015
21795555 Molecular mechanism of species-dependent sweet taste toward artificial sweeteners

Liu, B, Ha, M, Meng, XY, Kaur, T, Khaleduzzaman, M, Zhang, Z, Jiang, P, Li, X, Cui, M

J Neurosci 2011
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