NS2 (1B) binds DDX58

Stable Identifier
R-HSA-9717469
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
Synonyms
RSV 1B binds DDX58
ReviewStatus
5/5
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NS2 (1B) binds DDX58
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Human respiratory syncytial virus (RSV) nonstructural protein (NS2 or 1B) interacts with the N-terminal caspase activation recruitment domain (CARD) of DDX58 (RIG-I) upon co-expression in human embryonic kidney 293T (HEK293T) cells (Ling Z et al. 2009). Viral 1B also co-precipitates with endogenous DDX58 during RSV infection in human lung carcinoma (A549) cells. The binding of viral 1B (NS2) is believed to prevent CARD-CARD interactions between DDX58 and MAVS, thereby inhibiting DDX58 (RIG-I)-mediated induction of IFN. In summary, hRSV 1B acts as a multifunctional IFN antagonist, helping the virus to evade host innate immunity (Ling Z et al. 2009; Pei et al, 2021).
Literature References
PubMed ID Title Journal Year
33649232 Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2

Gross, ML, Chatterjee, S, Amarasinghe, GK, Wagner, ND, Pei, J, Basler, CF, Zou, AJ, Otwinowski, Z, Cole, AR, Borek, D, Leung, DW, Kim, PJ

Proc Natl Acad Sci U S A 2021
19193793 Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I

Ling, Z, Teng, MN, Tran, KC

J Virol 2009
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Authored
Shamovsky, V  (2021-03-10)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Shamovsky, V  (2021-03-10)
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