Reactome | SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol

SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol

Stable Identifier

R-HSA-9717374

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol

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SCN3A in combination with a regulatory beta subunit responds to depolarization by opening and passively transporting sodium ions according to the concentration gradient from the extracellular region to the cytosol (Vanoye et al. 2014, Zaman et al. 2018). In mouse type II taste cells, initial depolarization at the apex of the cell is believed to cause an activation potential via Scn2a, Scn3a, and Scn9a located at the basolateral membrane (Gao et al. 2009). Mutations in SCN3A cause infantile epilepsy (Vanoye et al. 2014, Zaman et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
29466837	Mutations in SCN3A cause early infantile epileptic encephalopathy Zaman, T, Helbig, I, Božović, IB, DeBrosse, SD, Bergqvist, AC, Wallis, K, Medne, L, Maver, A, Peterlin, B, Helbig, KL, Zhang, X, Goldberg, EM	Ann Neurol	2018
24157691	Novel SCN3A variants associated with focal epilepsy in children Vanoye, CG, Gurnett, CA, Holland, KD, George, AL, Kearney, JA	Neurobiol Dis	2014