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GNB1,3:GNG13 binds PLCB2:Ca2+
Stable Identifier
R-HSA-9717193
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
GNB1,3:GNG13 binds PLCB2:Ca2+ (Homo sapiens)
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The gustducin beta-gamma complex (GNB1,3:GNG13) dissociates from the umami receptor and interacts with phospholipase C beta-2 (PLCB2) at the plasma membrane (inferred from mouse, rat, and bovine homologs). In mouse taste cells, stimulation of IP3 synthesis by bitter tastants requires PLCB2 (Yan et al. 2001).
Participants
Input
GNB1,3:GNG13 [plasma membrane]
(Homo sapiens)
PLCB2:Ca2+ [cytosol]
(Homo sapiens)
Output
GNB1,3:GNG13:PLCB2:Ca2+ [plasma membrane]
(Homo sapiens)
Participates
as an event of
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
Inferred From
Gnb1:GNG2 binds PLCB2 (Bos taurus)
Authored
May, B (2021-03-05)
Reviewed
Jiang, P (2021-08-08)
Created
May, B (2021-03-08)
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